A. D. To search for procedures that may replace the use of animals, reduce the number of animals used, or refine the methodology to minimize animal pain or distress. A. A. A. D. A veterinarian, practicing scientist with experience in animal research, person who is not a scientist, and person who is not affiliated with the organization. Investigators must participate in all aspects of the Occupational Health and Safety Program, including immunizations. B. Pioneers cut bricks from sod-basically, prairie soil as a matrix, and grass and its root system as reinforcement. D Federal guidelines mandate the following minimum IACUC membership requirements for organizations that receive funding from PHS and utilize animals regulated by the AWA: a veterinarian, scientist experienced in animal research, person whose primary concerns are in a non-scientific area, and person who is unaffiliated with the organization. A. C. Animals should be monitored during the postoperative period. C. The veterinarian cannot exempt an animal, even for medical reasons. Some use accreditation as a symbol of qualityit shows that an institution is serious about setting, achieving and maintaining high standards for animal research programs. Ear punching and notching is the most permanent way to identify rodents. ", Which of the following Guides is best used as a source of guidance for animals used in agricultural research and teaching? C. Those organizations that accept U.S. Department of Agriculture (USDA) research funds. Why is it fitting that it is almost the last day of the summer in The Great Gatsby Chapter 7? Do you Cars lack adequate air circulation since they are enclosed places. The Johns Hopkins Center for Alternatives to Animal Testing (CAAT), the Institute for In Vitro Sciences, and the European Center for Validation of Alternative Methods (ECVAM) are primarily interested in what area? A. The principal investigator is responsible for ensuring all staff are trained to: All significant changes to an animal use protocol need to be approved by the IACUC. Currently nearly 900 companies, universities, hospitals, government agencies and other research institutions in 40+ countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use. B. The Council also appoints a roster of ad hoc Consultants/Specialists. Which of the following sets of IACUC members are required by the AWA and/or PHS? By ensuring that animal activities comply with animal welfare laws and guidelines, the IACUC ensures that animals are not subjected to unnecessary pain and distress; therefore, protecting both the investigator and organization. Which of the following sets of IACUC members are required by the AWA and/or PHS? A. It is good to assume that procedures that are painful for humans are also painful for animals. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be A. Which of the statements concerning blood collection in mice and rats is TRUE? Which of the following statements about identifying mice is NOT true? A simple rule to prevent excess blood collection in an animal is to collect no more than what percentage of body weight as blood at one time? C. Studies in which animals experiencing pain are allowed to die without pain relief. Which of the following can provide valuable information in assessing pain and distress in mice? If an investigator sees an animal that appears to be in immediate danger, what action should be taken first? A If investigators plan to contract with a commercial enterprise or other entity to produce custom antibodies, whether polyclonal or monoclonal, they must obtain approval from the IACUC. Dont worry, you wont be the first person to ask. D. Food should be withheld prior to surgery, but not water. Which of the following is a role of AAALAC International? B. Driving in the summer, winter, or rainy season may be to blame for the unpleasant odor inside the car. The Public Health Service (OLAW) Today, more than 900 organizations worldwide are accredited. What is the goal of an occupational health and safety program? Which of the following activities would disqualify an animal from USDA category D? Animal density in the euthanasia chamber is not a concern. The use of a new blood collection technique that causes less pain and distress. Determine when emergency IACUC meetings must be scheduled. The European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, Council of Europe (ETS 123). D. A change in surgical anesthetic. B. Over distension of the urinary and gall bladders. Wild birds. Which of the following statements about the postoperative period is FALSE? And perhaps most importantly, accreditation demonstrates a willingness to go above and beyond the minimums required by law, and assures the public that the institution is committed to the responsible use and treatment of animals in science. Which of the following institutions must follow PHS guidelines for animal research? D. The research technicians who perform the animal experiments. Submit a report to OLAW or USDA. C. Work in pairs. Dogs, cats, and primates The Board appoints AAALACs Council on Accreditation, the group responsible for evaluating animal programs and determining their accreditation status. B. The program must include time spent outside. IACUCs are not mandated to write the basic science portions of grant applications or animal use protocols for investigators. C. The list of citations and the date of the search. B The use of carbon dioxide in cylinders (not from dry ice) is the current recommended method of rodent euthanasia (AVMA recommendations on euthanasia) using a 20% replacement rate for the volume of carbon dioxide/cage or container. B. IACUCs are not responsible for investigating allegations of mistreatment, misuse, or noncompliance, as it is the investigators role to do so. C. While under anesthesia, mice should be monitored for cardiovascular and respiratory function and body temperature. Which of the following organizations must comply with the PHS Policy when utilizing vertebrate animals for research, teaching, or testing? B. Non-survival After any preliminary work with the animals that is needed to finalize the design of the procedures, but before the formal study begins. A. Dr. Helen Diggs, Senior Director at AAALAC International, will review AAALAC Internationals history and mission, accreditation standards, review process, and site visit trends, and the importance and value of AAALAC International accreditation. The standards in the Guide go above and beyond what is required by law. D. If an animal undergoes non-survival surgery, the fur around the surgical site should be clipped and clean instruments should be used. Enrollment in the institutional Occupational Health and Safety program is mandatory before working with animals. Humane endpoint criteria define the conditions under which: Those organizations that sell vertebrate animals for research, teaching, or testing. Why should an IP injection be made on the mouse's right side? Fish and Wildlife Service (FWS) candidates passport page showing personal particulars) when submitting an S Pass application.Documents requiredPersonal particulars page of candidates Do you want to achieve flawless skin without having to spend a fortune on makeup? The researchers and regulatory agencies only B. Postoperative care records should be maintained at least a year after the death of an animal. A change from non-survival to survival surgery Who is generally given institutional responsibility for deciding if an individual researcher is properly trained to perform animal procedures, as required by law? Methods of euthanasia deemed "acceptable with conditions" may require scientific justification before IACUC approval. In the mouse, IP injection should proceed only after aspiration has shown that the needle is properly positioned. A. UsingAAVrh10,Raetal.achievedgreaterefcacyin mice by either increasing the dose via combined route of administration,27 combination of systemic AAVrh10 with . D. A goal of sterile technique is to prevent contamination of the surgical site. C. Over enthusiastic grooming of dorsal fur or haircoat. Which of the following statements is TRUE? B. Sedation causes vasodilation which helps make the tail vein easier to find. For research on animal subjects, at what point must an investigator receive IACUC approval for the proposed animal activities and procedures? Restraint can be used as a normal component of animal housing, Restraint for brief periods of time during experimental procedures do not need to be mentioned in the animal use protocol. Daily observations are usually recorded during the postoperative period. Which of the following statements is NOT true about AAALAC International? It reflects the many linkages that tie channel members and other agencies together in the DOWNLOADS Since August 23, 2010 COinS Page 2 PDF Editorial Volume 4, Issue 3Ciorstan J. Smark PDF Book Review : Social and Environmental AccountingLee C. Moerman Page 3 PDF Editorial Volume What is the maximum number of emission lines when the excited electron of a H atom in n = 6 drops to the ground state? In this diverse landscape, AAALAC International uses performance standards to assure harmonization of accredited animal care and use programs globally. D. Convenience of the research and husbandry staff, According to the Guide, which housing is recommended preferentially for domesticated rodents? The investigator C. Zoonotic diseases are very common in specific-pathogen-free laboratory mice. The Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Which of the following activities would EXCLUDE an animal from USDA category D? Which of the following statements is/are TRUE regarding preparation of a mouse for surgery? A properly performed search for alternatives will likely also confirm that the animal model is appropriate and that no alternative models exist. Which of the following statements is true regarding research antibody production? Nonverbal communication is defined as how people communicate with each other without talking or writing. Which statement is true regarding care procedures for mice undergoing surgery? A. B. An anesthetic overdose is an acceptable method. B. Endpoint criteria describe when it is time to do what? B. Mammaries become visible on the females around 9 days. More than 1,000 companies, universities, hospitals, government agencies and other research institutions in 47 countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use. One book, The Guide for the Care and Use of Laboratory Animals serves as the basic standard represented by AAALAC accreditation. D. No later than when data collection from the animals begins. The floor space of the cage should be adequate to accommodate all mice on the cage floor, and respiration and heart beat cessation should be confirmed before disposal. Changes in animal ownership and movement of animals between facilities during the postoperative period. What is a problem that is often encountered with mice housed on wire mesh flooring? The 2015 memorandum of understanding between the NIH and NSF also mandates that organizations receiving NSF funding for animal research projects comply with the PHS Policy. 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